Rosacea and IBS show bidirectional association

A nationwide Korean cohort study finds 30% higher IBS and 61% higher rosacea hazards, with stronger associations among men.

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In a Korean population-based cohort, patients with rosacea had a 30% higher adjusted hazard of subsequently developing IBS than matched controls.
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Patients with IBS had a 61% higher adjusted hazard of subsequently developing rosacea, although the absolute incidence of rosacea remained low.
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The study included 712,331 adults and used matched cohorts and Cox models adjusted for sociodemographic factors and comorbidities.
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Bidirectional associations persisted in sensitivity analyses adjusting for isotretinoin, doxycycline, and minocycline exposure, but estimates were attenuated.
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The observational study could not establish causality, and administrative diagnoses, missing lifestyle and microbiome data, and health care use may have affected estimates.

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