Multidimensional exploration of the relationship between gut microbiota and colorectal cancer: focus on clinical tumorigenesis and treatment - Takeaways - MDSpire

Multidimensional exploration of the relationship between gut microbiota and colorectal cancer: focus on clinical tumorigenesis and treatment

  • By

  • Haiyu Zhang

  • Ke Zhang

  • Jichuan Liu

  • Hao Luo

  • May 7, 2026

  • 0 min

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  • 1

    The gut microbiome significantly influences colorectal cancer (CRC) development and management through complex interrelationships.

  • 2

    Gut dysbiosis is strongly correlated with CRC progression, impacting therapeutic responses and necessitating further research.

  • 3

    Microbial profiles and metabolites may facilitate colorectal carcinogenesis via genotoxic effects, inflammation, and immune dysregulation.

  • 4

    Novel therapeutic approaches targeting the gut microbiome include probiotics, prebiotics, and fecal microbiota transplantation.

  • 5

    A microbiota-immune-metabolism-therapy framework is proposed to unify tumorigenic mechanisms and treatment responsiveness in CRC.

Original Source(s)

Multidimensional exploration of the relationship between gut microbiota and colorectal cancer: focus on clinical tumorigenesis and treatment

  • by Haiyu Zhang, Ke Zhang, Jichuan Liu, Hao Luo

  • May 7, 2026

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