Familial associations of lymphoma and myeloma with autoimmune diseases - Takeaways - MDSpire

Familial associations of lymphoma and myeloma with autoimmune diseases

  • By

  • K Hemminki

  • A Försti

  • K Sundquist

  • J Sundquist

  • X Li

  • January 6, 2017

  • 0 min

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  • 1

    A personal history of autoimmune diseases (AIDs) is a known risk factor for B-cell neoplasms like Hodgkin lymphoma, multiple myeloma, and non-Hodgkin lymphoma.

  • 2

    Familial associations between AIDs and B-cell neoplasms suggest potential genetic etiology, with studies indicating increased risks for certain cancers linked to specific AIDs.

  • 3

    Increased risks for non-Hodgkin lymphoma were noted in families with histories of angiitis hypersensitive, Guillan-Barre, and discoid lupus erythematosus.

  • 4

    Families with pemphigus showed an increased risk for Hodgkin lymphoma, while those with glomerular nephritis acute had a decreased risk.

  • 5

    Overall, the study analyzed 64,418 neoplasms and 531,155 AIDs, revealing complex relationships between familial histories of AIDs and B-cell neoplasms.

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