Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design - Takeaways - MDSpire

Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design

  • By

  • Ryan E. Wiegand

  • Sean Chickery

  • Duck-Hye Yang

  • Sarah W. Ball

  • Malini B. DeSilva

  • Kristin Dascomb

  • Stephanie A. Irving

  • Karthik Natarajan

  • Nicola P. Klein

  • Shaun J. Grannis

  • Toan C. Ong

  • Elizabeth A. K. Rowley

  • Adam Yates

  • Yan Zhuang

  • Sarah Wilson

  • Charlene E. McEvoy

  • Inih J. Essien

  • Omobosola O. Akinsete

  • Allison L. Naleway

  • Padma Koppolu

  • Ousseny Zerbo

  • John R. Hansen

  • Karen B. Jacobson

  • Lawrence Block

  • Brian E. Dixon

  • Thomas Duszynski

  • Colin Rogerson

  • Michelle A. Barron

  • Catia Chavez

  • Josephine Mak

  • Allison Avrich Ciesla

  • Monica Godfrey

  • Amber Kautz

  • Morgan Najdowski

  • Ruth Link-Gelles

  • Jennifer DeCuir

  • Amanda B. Payne

  • June 23, 2026

  • 0 min

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  • 1

    COVID-19 was linked to an estimated 390,000 to 550,000 hospitalizations in the US from October 2024 to September 2025.

  • 2

    The FDA approved monovalent COVID-19 vaccines for 2025-2026 based on the Omicron LP.8.1 strain on August 27, 2025.

  • 3

    The study estimated vaccine effectiveness against COVID-19-related emergency department encounters and hospitalizations among immunocompetent adults.

  • 4

    A total of 85,725 encounters were analyzed, including 3,941 case patients with positive SARS-CoV-2 tests and 81,784 control patients.

  • 5

    Vaccination history was obtained from immunization information systems, electronic health records, and medical claims data.

Original Source(s)

Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design

  • by Ryan E. Wiegand, Sean Chickery, Duck-Hye Yang, Sarah W. Ball, Malini B. DeSilva, Kristin Dascomb, Stephanie A. Irving, Karthik Natarajan, Nicola P. Klein, Shaun J. Grannis, Toan C. Ong, Elizabeth A. K. Rowley, Adam Yates, Yan Zhuang, Sarah Wilson, Charlene E. McEvoy, Inih J. Essien, Omobosola O. Akinsete, Allison L. Naleway, Padma Koppolu, Ousseny Zerbo, John R. Hansen, Karen B. Jacobson, Lawrence Block, Brian E. Dixon, Thomas Duszynski, Colin Rogerson, Michelle A. Barron, Catia Chavez, Josephine Mak, Allison Avrich Ciesla, Monica Godfrey, Amber Kautz, Morgan Najdowski, Ruth Link-Gelles, Jennifer DeCuir, Amanda B. Payne

  • June 23, 2026

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