Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort - Takeaways - MDSpire

Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort

  • By

  • Qiong Wu

  • Jian Peng

  • Xiangzhi Xiao

  • Huashan Zhou

  • Yan Ouyang

  • Sufen Chen

  • Jue Hu

  • Yanhua Zhou

  • Tieqiao Feng

  • Wengao Zeng

  • June 11, 2026

  • 0 min

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  • 1

    Drug-induced liver injury (DILI) occurred in 13.8% of 1,574 hospitalized non-HIV patients with tuberculous meningitis (TBM).

  • 2

    DILI was independently associated with an 8.5-fold increased risk of in-hospital mortality in TBM patients, with consistent results across various analyses.

  • 3

    The median time from the initiation of anti-tuberculosis treatment to DILI onset was 23 days, indicating a significant delay before liver injury manifests.

  • 4

    Adding DILI to mortality risk models improved predictive accuracy, increasing the area under the curve from 0.661 to 0.805.

  • 5

    The study suggests a potential age-related modification in the DILI-mortality association, warranting further investigation into age-specific effects.

Original Source(s)

Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort

  • by Qiong Wu, Jian Peng, Xiangzhi Xiao, Huashan Zhou, Yan Ouyang, Sufen Chen, Jue Hu, Yanhua Zhou, Tieqiao Feng, Wengao Zeng

  • June 11, 2026

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