Polymyxin B-induced gastric spasm:a case report - Takeaways - MDSpire

Polymyxin B-induced gastric spasm:a case report

  • By

  • Chuan Sun

  • Yao Sun

  • Dandan Yang

  • Tianjiao Hu

  • Lihua Yuan

  • June 22, 2026

  • 0 min

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  • 1

    Polymyxin B is used to treat carbapenem-resistant Acinetobacter baumannii infections but can cause adverse reactions.

  • 2

    A 14-year-old boy developed severe gastric spasm after receiving polymyxin B, which resolved upon discontinuation of the drug.

  • 3

    The patient's symptoms included abdominal colic, nausea, and vomiting, with a CT scan showing gastric wall thickening.

  • 4

    Polymyxin B may elevate histamine levels, leading to increased gastric acid secretion and compromised gastric mucosal barrier.

  • 5

    The Naranjo algorithm indicated a probable causal link between polymyxin B and the gastric spasm in this case.

Original Source(s)

Polymyxin B-induced gastric spasm:a case report

  • by Chuan Sun, Yao Sun, Dandan Yang, Tianjiao Hu, Lihua Yuan

  • June 22, 2026

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