The role of the NLRP3 inflammasome in hypertension-related chronic heart failure and its potential therapeutic targets

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Hypertension-induced pressure overload is a significant contributor to chronic heart failure (CHF) and is associated with persistent sterile inflammation.
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The study utilized a transverse aortic constriction (TAC) mouse model to evaluate the role of the ATP–P2X7–NLRP3 inflammasome axis in CHF.
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Pressure overload led to stage-dependent activation of the ATP–P2X7 signaling pathway and NLRP3 inflammasome, correlating with cardiac dysfunction.
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Pharmacologic or genetic disruption of the ATP–P2X7–NLRP3 axis reduced inflammasome signaling and improved cardiac structure and function.
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The ATP–P2X7–NLRP3 axis may serve as a potential therapeutic target for managing hypertension-related chronic heart failure.

Frontiers In Immunology

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