Pre-transplant measurable residual disease by flow cytometry is an independent prognostic factor in pediatric acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation - Takeaways - MDSpire

Pre-transplant measurable residual disease by flow cytometry is an independent prognostic factor in pediatric acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation

  • By

  • Shaoyang Deng

  • Shan He

  • Na Song

  • Zhijun Huang

  • Benshan Zhang

  • July 17, 2026

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  • 1

    Pre-transplant measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) serves as an independent prognostic factor in pediatric AML.

  • 2

    The study included 80 pediatric AML patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) during their first complete remission.

  • 3

    The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.5% and 86.8%, respectively, with pre-transplant MFC-MRD positivity linked to poorer outcomes.

  • 4

    Multivariate analysis confirmed pre-transplant MFC-MRD positivity as an adverse prognostic factor for both DFS and OS in pediatric AML patients.

  • 5

    Patients with high-risk fusion genes, such as NUP98 rearrangements, may remain at risk of relapse post-transplantation, though findings require further validation.

Original Source(s)

Pre-transplant measurable residual disease by flow cytometry is an independent prognostic factor in pediatric acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation

  • by Shaoyang Deng, Shan He, Na Song, Zhijun Huang, Benshan Zhang

  • July 17, 2026

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