Prevalence and influencing factors of cognitive frailty in patients with chronic heart failure: a meta-analysis - Takeaways - MDSpire

Cognitive Frailty in Chronic Heart Failure Patients: A Meta-Analysis of Prevalence and Contributing Factors

  • By

  • Meiwan Zhang

  • Chen Zhou

  • Min Hu

  • Chi Tian

  • Jiayue Zeng

  • July 20, 2026

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  • 1

    The meta-analysis included 14 studies with 5,127 chronic heart failure patients, revealing a cognitive frailty prevalence of 39.3%.

  • 2

    Age, NYHA classification, comorbidity burden, polypharmacy, malnutrition, and depression were identified as significant risk factors for cognitive impairment.

  • 3

    Protective factors against cognitive impairment included higher educational attainment, physical exercise ≥ 3 times per week, and regular intellectual activities.

  • 4

    Cognitive frailty is associated with increased mortality and readmission rates in chronic heart failure patients.

  • 5

    The study emphasizes the need for routine cognitive function screening and targeted interventions in chronic heart failure populations.

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