Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation

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Sepsis is a leading cause of mortality in critical care, driven by dysregulated inflammatory responses and complex cellular mechanisms.
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A six-gene necroptosis signature was identified, correlating with sepsis severity and outcomes in a cohort of 1,265 patients.
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CD177+ neutrophils were significantly enriched in non-surviving sepsis patients and exhibited heightened necroptosis transcriptional scores.
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Machine learning models incorporating the necroptosis signature demonstrated robust diagnostic performance across independent cohorts.
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The study suggests that CD177+ neutrophils may play a role in necroptosis-related inflammation in sepsis, warranting further exploration.

Frontiers In Immunology

by Haibo Liu, Xiangshu Cheng, Jun Li, Wei Wei, Yijia Yuan, Wenjuan Wang, Wei Wang, Fang Liu, Jin Zheng
July 3, 2026

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