Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation - Takeaways - MDSpire
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Elevated CD177 Expression on Neutrophils Associated with Sepsis Development and Inflammation Mediated by Necroptosis

  • By

  • Haibo Liu

  • Xiangshu Cheng

  • Jun Li

  • Wei Wei

  • Yijia Yuan

  • Wenjuan Wang

  • Wei Wang

  • Fang Liu

  • Jin Zheng

  • July 3, 2026

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  • 1

    Sepsis is a leading cause of mortality in critical care, driven by dysregulated inflammatory responses and complex cellular mechanisms.

  • 2

    A six-gene necroptosis signature was identified, correlating with sepsis severity and outcomes in a cohort of 1,265 patients.

  • 3

    CD177+ neutrophils were significantly enriched in non-surviving sepsis patients and exhibited heightened necroptosis transcriptional scores.

  • 4

    Machine learning models incorporating the necroptosis signature demonstrated robust diagnostic performance across independent cohorts.

  • 5

    The study suggests that CD177+ neutrophils may play a role in necroptosis-related inflammation in sepsis, warranting further exploration.

Original Source(s)

Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation

  • by Haibo Liu, Xiangshu Cheng, Jun Li, Wei Wei, Yijia Yuan, Wenjuan Wang, Wei Wang, Fang Liu, Jin Zheng

  • July 3, 2026

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