CCL25 chemokine promotes antiviral tissue resident CD4+ and CD8+ effector memory TRM cells associated with a reduction of ocular herpes infection and disease: a potential gut–eye axis in herpes immunity - Takeaways - MDSpire

CCL25 chemokine promotes antiviral tissue resident CD4+ and CD8+ effector memory TRM cells associated with a reduction of ocular herpes infection and disease: a potential gut–eye axis in herpes immunity

  • By

  • Azizur Rahman

  • Swayam Prakash

  • Sweta Karan

  • Sarah Xue Le Ng

  • Gina Park

  • Chhaya Maurya

  • America Garcia

  • Khan Intharachalit

  • Junseong Hwang

  • Celine Tze Yao Tang

  • Reilly Andrew Chow

  • Baverly Sabathini Suoth

  • Emma Jane Liao

  • Lbachir BenMohamed

  • July 17, 2026

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  • 1

    CCL25 is a gut-derived chemokine that plays a significant role in enhancing ocular immunity during HSV-1 infection.

  • 2

    CCL25 deficiency in mice resulted in increased corneal disease severity and reduced survival following HSV-1 infection.

  • 3

    Fewer antiviral effector memory CD4+ and CD8+ T cells were found in CCL25-deficient mice compared to wild-type controls.

  • 4

    CCL25 influences the expression of other mucosal chemokines, which are crucial for T cell trafficking during ocular HSV-1 infection.

  • 5

    The study supports the concept of a gut-eye axis in herpes immunity, suggesting CCL25 as a potential therapeutic target.

Original Source(s)

CCL25 chemokine promotes antiviral tissue resident CD4+ and CD8+ effector memory TRM cells associated with a reduction of ocular herpes infection and disease: a potential gut–eye axis in herpes immunity

  • by Azizur Rahman, Swayam Prakash, Sweta Karan, Sarah Xue Le Ng, Gina Park, Chhaya Maurya, America Garcia, Khan Intharachalit, Junseong Hwang, Celine Tze Yao Tang, Reilly Andrew Chow, Baverly Sabathini Suoth, Emma Jane Liao, Lbachir BenMohamed

  • July 17, 2026

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