GlycoRNA represents a new class of biomolecules that challenges traditional views of glycosylation, previously focused on proteins and lipids.
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Mass spectrometry is essential for analyzing glycoRNA, encompassing a comprehensive workflow from sample collection to final analysis.
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Sample handling and enrichment strategies are critical due to the short and rare nature of glycoRNA, with methods like metabolic labeling enhancing detection.
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Distinct glycan signatures in glycoRNA across cell types may serve as biomarkers for disease diagnosis and prognosis.
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Despite challenges in abundance and contamination, the review establishes mass spectrometry-based glycomics as vital for advancing glycoRNA research.
