Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses - Takeaways - MDSpire

Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses

  • By

  • Jia Li

  • Jinling Li

  • Yuechao Zhao

  • Yuanqi Yu

  • Xiaolu Cui

  • July 13, 2026

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  • 1

    Androgen receptor signaling inhibitors have improved advanced prostate cancer treatment, but therapy-resistant states like NEPC and DNPC limit durable responses.

  • 2

    Tumor-associated macrophages influence tumor-cell state transitions and therapeutic resistance in prostate cancer through their heterogeneity.

  • 3

    Established myeloid programs and emerging TAM states, such as PLAC8+ TAMs, are linked to lineage plasticity in prostate cancer.

  • 4

    Single-cell and spatial transcriptomic studies reveal extensive TAM heterogeneity, impacting tumor progression and treatment outcomes.

  • 5

    The review emphasizes distinguishing established findings from emerging observations in TAM research to guide future therapeutic strategies.

Original Source(s)

Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses

  • by Jia Li, Jinling Li, Yuechao Zhao, Yuanqi Yu, Xiaolu Cui

  • July 13, 2026

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