Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Triphenyl Phosphate Induces Lipid Accumulation in Human Mesenchymal Stem Cells via Metabolic Stress Mechanisms

  • By

  • M. C. Gronske

  • W. Stutts

  • D. Jima

  • J. Palumbo

  • H. M. Stapleton

  • S. W. Kullman

  • June 2, 2026

Share

  • 1

    Triphenyl Phosphate (TPhP) is a prevalent organophosphate flame retardant found in indoor dust and surface waters.

  • 2

    TPhP exposure is linked to adverse health outcomes, including neurotoxicity, developmental toxicity, and metabolic disorders.

  • 3

    In vitro studies show that TPhP induces lipid accumulation in human mesenchymal stem cells, affecting their differentiation.

  • 4

    TPhP may disrupt metabolic balance, contributing to obesity and related metabolic health risks through endocrine disruption.

  • 5

    The study investigates TPhP's role in lipid production in human mesenchymal stem cells programmed to become osteoblasts.

Original Source(s)

Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways

  • by M. C. Gronske, W. Stutts, D. Jima, J. Palumbo, H. M. Stapleton, S. W. Kullman

  • June 2, 2026

Related Content

Case Report: ACTH-independent Cushing’s syndrome caused by isolated micronodular adrenal disease in a 23-month-old girl

Virtual Preoperative Education in Bariatric Surgery: Patient Acceptance and Travel-Related Carbon Savings

Dietary fibers to boost endogenous GLP-1 secretion and satiety: a scoping review