Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways - Takeaways - MDSpire

Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways

  • By

  • M. C. Gronske

  • W. Stutts

  • D. Jima

  • J. Palumbo

  • H. M. Stapleton

  • S. W. Kullman

  • June 2, 2026

  • 0 min

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  • 1

    Triphenyl Phosphate (TPhP) is a prevalent organophosphate flame retardant found in indoor dust and surface waters.

  • 2

    TPhP exposure is linked to adverse health outcomes, including neurotoxicity, developmental toxicity, and metabolic disorders.

  • 3

    In vitro studies show that TPhP induces lipid accumulation in human mesenchymal stem cells, affecting their differentiation.

  • 4

    TPhP may disrupt metabolic balance, contributing to obesity and related metabolic health risks through endocrine disruption.

  • 5

    The study investigates TPhP's role in lipid production in human mesenchymal stem cells programmed to become osteoblasts.

Original Source(s)

Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways

  • by M. C. Gronske, W. Stutts, D. Jima, J. Palumbo, H. M. Stapleton, S. W. Kullman

  • June 2, 2026

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