Effects of surgery on cancer metastasis: biological mechanisms and perioperative implications - Takeaways - MDSpire

Effects of surgery on cancer metastasis: biological mechanisms and perioperative implications

  • By

  • Mwangala Nalisa

  • Thifhelimbilu Emmanuel Luvhengo

  • Petrina Kapewangolo

  • June 18, 2026

  • 0 min

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  • 1

    Surgical interventions can inadvertently promote cancer metastasis through systemic inflammation and immune suppression during the perioperative period.

  • 2

    Tissue injury from surgery triggers the release of cytokines and damage-associated molecular patterns that enhance tumor cell survival and dissemination.

  • 3

    The perioperative period is characterized by a transient reduction in natural killer cell and cytotoxic T-cell activity, facilitating circulating tumor cell outgrowth.

  • 4

    Emerging strategies to mitigate metastatic risk include prehabilitation, immunomodulation, and minimally invasive surgical approaches.

  • 5

    A comprehensive understanding of perioperative biological changes can inform integrated oncology strategies to improve long-term cancer outcomes.

Original Source(s)

Effects of surgery on cancer metastasis: biological mechanisms and perioperative implications

  • by Mwangala Nalisa, Thifhelimbilu Emmanuel Luvhengo, Petrina Kapewangolo

  • June 18, 2026

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