Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO2max and speckle tracking echocardiography - Takeaways - MDSpire

Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO2max and speckle tracking echocardiography

  • By

  • Ignacio Ruiz del Olmo-Izuzquiza

  • Antonio de Arriba-Muñoz

  • Lorenzo Jiménez-Montañés

  • Ángel Matute-Llorente

  • Marta Vara-Callau

  • Marta Ferrer-Lozano

  • José-Antonio Casajús-Mallén

  • José-Ignacio Labarta-Aizpún

  • May 28, 2026

  • 0 min

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  • 1

    The study evaluated the effects of recombinant human growth hormone (r-hGH) on aerobic capacity and cardiac function in short-statured prepubertal children.

  • 2

    Thirty children participated, including 18 with growth hormone deficiency (GHD) and 12 non-GHD, receiving r-hGH for 12 months.

  • 3

    r-hGH therapy significantly increased IGF-1 levels and left ventricular mass indices, but VO2max showed no overall improvement.

  • 4

    GHD children, particularly girls, experienced a significant decrease in VO2max despite high adherence to therapy.

  • 5

    Speckle tracking echocardiography revealed early improvements in myocardial contractility in GHD patients, although GLS remained unchanged.

Original Source(s)

Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO2max and speckle tracking echocardiography

  • by Ignacio Ruiz del Olmo-Izuzquiza, Antonio de Arriba-Muñoz, Lorenzo Jiménez-Montañés, Ángel Matute-Llorente, Marta Vara-Callau, Marta Ferrer-Lozano, José-Antonio Casajús-Mallén, José-Ignacio Labarta-Aizpún

  • May 28, 2026

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