Bipolar disorder in people with multiple sclerosis: an updated systematic review and meta-analysis - Takeaways - MDSpire

Bipolar disorder in people with multiple sclerosis: an updated systematic review and meta-analysis

  • By

  • Omid Mirmosayyeb

  • Saeed Vaheb

  • Aysa Shaygannejad

  • Elaheh Foroughi

  • Mohammad Yazdan Panah

  • Vahid Shaygannejad

  • January 29, 2026

  • 0 min

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  • 1

    Multiple Sclerosis (MS) is a chronic autoimmune disease that significantly impacts quality of life and causes various neurological symptoms.

  • 2

    Bipolar disorder (BD) is a chronic mood disorder that can co-occur with MS, complicating diagnosis and treatment.

  • 3

    The prevalence of BD in individuals with MS varies widely, reported between 0% and 16.2%, indicating a need for further research.

  • 4

    BD in MS patients is associated with reduced medication adherence and poorer quality of life, highlighting its clinical significance.

  • 5

    This systematic review and meta-analysis aims to estimate the prevalence of BD among MS patients and explore their association.

Original Source(s)

Bipolar disorder in people with multiple sclerosis: an updated systematic review and meta-analysis

  • by Omid Mirmosayyeb, Saeed Vaheb, Aysa Shaygannejad, Elaheh Foroughi, Mohammad Yazdan Panah, Vahid Shaygannejad

  • January 29, 2026

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