Neurofilament light and glial fibrillary acidic protein do not reflect neuronal or glial damage during different intracranial radiotherapy regimes: a pilot study - Takeaways - MDSpire

Neurofilament light and glial fibrillary acidic protein do not reflect neuronal or glial damage during different intracranial radiotherapy regimes: a pilot study

  • By

  • Yvonne Dzierma

  • Holger Sebb

  • Michael Utzig

  • Nurlan Abdullayev

  • Christian Berdel

  • Christian Ruebe

  • Jochen Fleckenstein

  • Markus Hecht

  • Guido Hildebrandt

  • Mathias Jucker

  • Kristina Heyne

  • June 8, 2026

  • 0 min

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  • 1

    Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are non-specific markers of central nervous system damage.

  • 2

    This pilot study measured NfL and GFAP levels in patients undergoing various radiotherapy protocols for brain tumors.

  • 3

    Elevated NfL and GFAP levels were confirmed in all patients before radiotherapy, but significant increases were not observed during treatment.

  • 4

    Decreasing NfL and GFAP values during follow-up correlated with treatment response, while increases indicated new cerebral lesions.

  • 5

    Cerebral radiation injury does not correlate with increased NfL and GFAP levels during radiotherapy, suggesting their potential for follow-up.

Original Source(s)

Neurofilament light and glial fibrillary acidic protein do not reflect neuronal or glial damage during different intracranial radiotherapy regimes: a pilot study

  • by Yvonne Dzierma, Holger Sebb, Michael Utzig, Nurlan Abdullayev, Christian Berdel, Christian Ruebe, Jochen Fleckenstein, Markus Hecht, Guido Hildebrandt, Mathias Jucker, Kristina Heyne

  • June 8, 2026

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