Intermittent Theta-Burst Stimulation for Depressive Symptoms in Parkinson Disease: A Randomized Clinical Trial - Takeaways - MDSpire

Intermittent Theta-Burst Stimulation for Depressive Symptoms in Parkinson Disease: A Randomized Clinical Trial

  • By

  • Miaomiao Hou

  • Bingjie Tian

  • Chen Qi

  • Lu Song

  • Bingjie Ma

  • Xinxin Chen

  • Ying Wan

  • Na Wu

  • Jing Gan

  • Zhenguo Liu

  • Yu Zhang

  • May 20, 2026

  • 0 min

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  • 1

    Depressive symptoms affect 20% to 50% of patients with Parkinson disease, impacting their quality of life and motor function.

  • 2

    Intermittent theta-burst stimulation (iTBS) offers a brief 3-minute session alternative to high-frequency rTMS for treating depression in Parkinson's disease.

  • 3

    A randomized clinical trial compared iTBS, HF-rTMS, and sham stimulation to evaluate their efficacy in alleviating depressive symptoms in Parkinson's disease.

  • 4

    The study included 54 patients with mild depressive symptoms, assessing outcomes using the HAMD-24 and other scales over a 6-week period.

  • 5

    Results indicated that both active interventions, iTBS and HF-rTMS, were superior to sham stimulation in reducing depressive symptoms in patients with PD.

Original Source(s)

Intermittent Theta-Burst Stimulation for Depressive Symptoms in Parkinson Disease: A Randomized Clinical Trial

  • by Miaomiao Hou, Bingjie Tian, Chen Qi, Lu Song, Bingjie Ma, Xinxin Chen, Ying Wan, Na Wu, Jing Gan, Zhenguo Liu, Yu Zhang

  • May 20, 2026

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