Adipose–muscle crosstalk during the menopausal transition: mechanistic links to sarcopenic obesity in midlife women - Takeaways - MDSpire

Adipose–muscle crosstalk during the menopausal transition: mechanistic links to sarcopenic obesity in midlife women

  • By

  • Weixin Zhang

  • Qianhao Wu

  • Qianyuan Chen

  • Wenxing Qin

  • Dongfang Zhang

  • Qingrong Xu

  • Peipei Han

  • Ji Sun

  • May 4, 2026

  • 0 min

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  • 1

    Midlife in women marks a biological transition that increases the risk of sarcopenic obesity despite stable BMI.

  • 2

    The final menstrual period is a critical time for accelerated fat accumulation and lean mass decline.

  • 3

    Myosteatosis, the accumulation of fat within muscle, negatively impacts strength and is linked to metabolic disorders.

  • 4

    Estrogen depletion during menopause disrupts muscle function and regenerative capacity, contributing to sarcopenic obesity.

  • 5

    Standardized definitions for sarcopenic obesity that include muscle quality and ectopic fat are essential for prevention.

Original Source(s)

Adipose–muscle crosstalk during the menopausal transition: mechanistic links to sarcopenic obesity in midlife women

  • by Weixin Zhang, Qianhao Wu, Qianyuan Chen, Wenxing Qin, Dongfang Zhang, Qingrong Xu, Peipei Han, Ji Sun

  • May 4, 2026

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