Tirofiban After Tenecteplase in Stroke - Takeaways - MDSpire
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Tirofiban After Tenecteplase in Stroke

Adjunctive tirofiban was linked to higher rates of positive 90-day outcomes in acute ischemic stroke.

  • By

  • Kathryn Wighton

  • May 14, 2026

  • 6 min

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  • 1

    The INSTANT trial found that tirofiban improved functional outcomes at 90 days in stroke patients with inadequate response to tenecteplase.

  • 2

    In the trial, 64% of patients receiving tirofiban achieved an excellent outcome, compared to 52% receiving placebo.

  • 3

    The trial included 359 patients with acute ischemic stroke and excluded those with large-vessel occlusion or cardioembolic sources.

  • 4

    Tirofiban was administered after tenecteplase, with a number needed to treat of 8.7 for achieving excellent outcomes.

  • 5

    The study's findings may not apply to patients with minor strokes or those treated outside the early thrombolysis window.

Original Source(s)

Tirofiban After Tenecteplase in Stroke

  • by Kathryn Wighton

  • May 14, 2026

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