Antivirals Linked to Lower Hospitalization in Influenza

Matched cohort study in nonhospitalized patients

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Antiviral treatment significantly reduced hospitalization, ICU admission, and mortality in nonhospitalized patients with influenza.
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In a study of 426,275 patients, hospitalization rates were 1.54% for treated patients versus 1.70% for untreated patients.
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Oseltamivir showed consistent benefits across secondary outcomes, while baloxavir had fewer primary outcome events.
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Subgroup analyses indicated hospitalization reductions in both adult and pediatric patients, with regional variations noted.
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The study's limitations included potential confounding factors and incomplete documentation, necessitating cautious interpretation of results.

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