Rethinking post-sepsis syndrome: linking cellular dysfunction to the clinical picture - Takeaways - MDSpire

Rethinking post-sepsis syndrome: linking cellular dysfunction to the clinical picture

  • By

  • Gabriel-Petre Gorecki

  • Andrei Bodor

  • Marius-Bogdan Novac

  • Dan-Gabriel Costea

  • Daniel-Ovidiu Costea

  • Andreea-Cristina Costea

  • Cătălin-Nicolae Grasa

  • Dana-Rodica Tomescu

  • October 2, 2025

  • 0 min

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  • 1

    Post-Sepsis Syndrome (PSS) encompasses symptoms like chronic fatigue and cognitive decline, with unclear molecular mechanisms.

  • 2

    Neutrophil extracellular traps (NETs) may contribute to inflammation and coagulopathy in sepsis survivors, linking chronic inflammation to immunothrombosis.

  • 3

    Mitochondrial dysfunction plays a critical role in the pathogenesis of PSS, affecting energy metabolism and immune regulation.

  • 4

    Damage-associated molecular patterns (DAMPs) perpetuate inflammation post-sepsis, influencing immune dysregulation through various pathways.

  • 5

    Understanding the mechanisms of PSS is vital for identifying biomarkers and therapeutic targets for improved patient outcomes.

Original Source(s)

Rethinking post-sepsis syndrome: linking cellular dysfunction to the clinical picture

  • by Gabriel-Petre Gorecki, Andrei Bodor, Marius-Bogdan Novac, Dan-Gabriel Costea, Daniel-Ovidiu Costea, Andreea-Cristina Costea, Cătălin-Nicolae Grasa, Dana-Rodica Tomescu

  • October 2, 2025

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