Case Report of Systemic Lupus Erythematosus Presenting as Japanese Spotted Fever with Rickettsia japonica Identified in an Eschar - Takeaways - MDSpire

Case Report of Systemic Lupus Erythematosus Presenting as Japanese Spotted Fever with Rickettsia japonica Identified in an Eschar

  • By

  • Kento Izuta

  • Masashi Nishikubo

  • Ryohei Nomoto

  • Shuji Sumitomo

  • Yoshinori Matsuoka

  • Ryutaro Seo

  • Hiroaki Nishioka

  • Koichi Ariyoshi

  • Eiichiro Sando

  • February 24, 2026

  • 0 min

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  • 1

    Neuropsychiatric systemic lupus erythematosus (NPSLE) presents with neurological symptoms and requires exclusion of other causes for diagnosis.

  • 2

    Japanese spotted fever (JSF) is a tick-borne disease caused by Rickettsia japonica, characterized by fever, rash, and black eschars.

  • 3

    SLE and JSF share symptoms like fever and cytopenia, complicating differential diagnosis, especially in severe cases.

  • 4

    A 43-year-old man with respiratory failure and altered consciousness presented diagnostic challenges due to overlapping symptoms of NPSLE and JSF.

  • 5

    Immediate intervention is crucial in critical care settings, even when the diagnosis remains uncertain due to complex clinical presentations.

Original Source(s)

Case Report of Systemic Lupus Erythematosus Presenting as Japanese Spotted Fever with Rickettsia japonica Identified in an Eschar

  • by Kento Izuta, Masashi Nishikubo, Ryohei Nomoto, Shuji Sumitomo, Yoshinori Matsuoka, Ryutaro Seo, Hiroaki Nishioka, Koichi Ariyoshi, Eiichiro Sando

  • February 24, 2026

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