Effects of endurance exercise on skeletal muscle and liver metabolic health in male rats with different fitness under chronic circadian rhythm disruption - Takeaways - MDSpire

Effects of endurance exercise on skeletal muscle and liver metabolic health in male rats with different fitness under chronic circadian rhythm disruption

  • By

  • Yu Gu

  • Wenduo Liu

  • Zilin Wang

  • Sang Hyun Kim

  • July 15, 2026

Share

  • 1

    Circadian rhythm disruption impairs metabolic function in skeletal muscle and liver, affecting mitochondrial biogenesis and substrate metabolism.

  • 2

    Endurance training mitigates metabolic dysfunction caused by circadian rhythm disruption, improving mitochondrial and metabolic adaptations.

  • 3

    Prolonged endurance training prior to or during circadian disruption leads to greater metabolic improvements than shorter training durations.

  • 4

    CR disruption increases oxidative stress, hepatic lipid accumulation, and fibrosis-related markers in skeletal muscle and liver.

  • 5

    Exercise timing and training duration are critical factors influencing metabolic resilience under conditions of circadian disruption.

Original Source(s)

Effects of endurance exercise on skeletal muscle and liver metabolic health in male rats with different fitness under chronic circadian rhythm disruption

  • by Yu Gu, Wenduo Liu, Zilin Wang, Sang Hyun Kim

  • July 15, 2026

Related Content

Three-year longitudinal assessment of denosumab’s efficacy and safety in postmenopausal osteoporosis: a 36-month real-world cohort study

Acute TRPTI™ (oleoylethanolamide) supplementation enhances incretin hormone responses: a fixed-sequence crossover study

Hysterectomy accelerates sarcopenia risk in US women and mouse models