Immediate prediction of post-ERCP pancreatitis: a novel approach using serum trypsin

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Post-ERCP pancreatitis (PEP) occurs in approximately 5–15% of ERCP cases and can be severe, requiring intensive care.
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Serum amylase (AMY) levels are commonly used to predict PEP, with levels exceeding twice the upper limit of normal indicating high incidence.
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Measuring serum trypsin (TRY) levels may allow for earlier detection of PEP compared to AMY or lipase levels.
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This study involved a multicenter observational design across 12 hospitals in Japan to assess TRY as a predictive marker for PEP.
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Patients were included if they were ≥ 20 years old with an intact papilla and excluded if they had acute pancreatitis or were on dialysis.

Journal Of Gastroenterology

by Takashi Tamura, Seiji Fujigaki, Tsuyoshi Sanuki, Tetsuya Ikeda, Satoshi Sugimori, Tsukasa Ikeura, Shinji Nakayama, Tomoya Emori, Kazuhiro Fukatsu, Yasutaka Ishii, Shiro Oka, Kenji Ikezawa, Ryoji Takada, Masanori Asada, Ayana Kishibuchi, Takeshi Ogura, Nobu Nishioka, Masaaki Shimatani, Masataka Kano, Arata Sakai, Kae Nagao, Shuhei Shintani, Osamu Inatomi, Masayuki Kitano
July 7, 2026

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