Niche-derived exosomes control Drosophila immune stress hematopoiesis - Takeaways - MDSpire

Niche-derived exosomes control Drosophila immune stress hematopoiesis

  • By

  • Nathalie Vanzo

  • Marianne Montemurro

  • Christian Rouvière

  • Léonie Gargouil

  • Vanessa Soldan

  • Michèle Crozatier

  • June 10, 2026

  • 0 min

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  • 1

    The Drosophila hematopoietic niche releases extracellular vesicles that regulate blood cell progenitor homeostasis during immune stress.

  • 2

    Exosomes from the niche activate the EGFR pathway in lymph gland progenitors, promoting differentiation into lamellocytes.

  • 3

    Wasp parasitism induces ROS elevation in the niche, leading to the release of a heterogeneous population of extracellular vesicles.

  • 4

    The metalloproteinase Mmp1 is required for exosome spreading through the extracellular matrix of the niche.

  • 5

    This study establishes the Drosophila lymph gland as a model for investigating exosome-mediated communication in hematopoiesis.

Original Source(s)

Niche-derived exosomes control Drosophila immune stress hematopoiesis

  • by Nathalie Vanzo, Marianne Montemurro, Christian Rouvière, Léonie Gargouil, Vanessa Soldan, Michèle Crozatier

  • June 10, 2026

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