Efficacy and safety of neoadjuvant chemotherapy with immunotherapy versus chemotherapy alone in esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials - Takeaways - MDSpire

Efficacy and safety of neoadjuvant chemotherapy with immunotherapy versus chemotherapy alone in esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials

  • By

  • Yibang Ye

  • Liangyu Zhang

  • Zhenyuan Yang

  • Yizhou Huang

  • Maohui Chen

  • Shuliang Zhang

  • Taidui Zeng

  • Chun Chen

  • Bin Zheng

  • July 9, 2026

  • 0 min

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  • 1

    Neoadjuvant chemoimmunotherapy (NIC) significantly improves major pathological response (MPR) and pathological complete response (pCR) in resectable esophageal squamous cell carcinoma (ESCC).

  • 2

    The meta-analysis included six high-quality randomized controlled trials (RCTs) with a total of 1070 patients comparing NIC and neoadjuvant chemotherapy (NC).

  • 3

    NIC was associated with borderline statistically significant improvements in overall survival (OS) and R0 resection rate compared to NC.

  • 4

    NIC enhanced surgical rates and lymph node resection but had a higher incidence of immune-related adverse events (iRAEs) compared to NC.

  • 5

    Further studies are needed to optimize treatment protocols and clarify the long-term impact of immune-related toxicities in ESCC.

Original Source(s)

Efficacy and safety of neoadjuvant chemotherapy with immunotherapy versus chemotherapy alone in esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials

  • by Yibang Ye, Liangyu Zhang, Zhenyuan Yang, Yizhou Huang, Maohui Chen, Shuliang Zhang, Taidui Zeng, Chun Chen, Bin Zheng

  • July 9, 2026

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