Temple Syndrome: Comprehensive Clinical Study in Genetically Confirmed 60 Japanese Patients - Takeaways - MDSpire

Temple Syndrome: Comprehensive Clinical Study in Genetically Confirmed 60 Japanese Patients

  • By

  • Tomoe Ogawa

  • Hiromune Narusawa

  • Keisuke Nagasaki

  • Rika Kosaki

  • Yasuhiro Naiki

  • Michihiko Aramaki

  • Keiko Matsubara

  • Akie Nakamura

  • Maki Fukami

  • Tsutomu Ogata

  • Masayo Kagami

  • December 18, 2024

  • 0 min

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  • 1

    Temple syndrome (TS14) is a rare imprinting disorder linked to chromosome 14q32.2, affecting growth and development.

  • 2

    In a study of 60 Japanese patients, common features included short stature, central precocious puberty, and developmental disabilities.

  • 3

    Growth hormone therapy improved height in patients, while GnRH analog therapy effectively managed central precocious puberty.

  • 4

    Metabolic complications such as hypercholesterolemia and diabetes mellitus were prevalent, often preceding obesity.

  • 5

    The study provides insights for diagnosing and managing TS14, emphasizing the need for long-term monitoring of affected individuals.

Original Source(s)

Temple Syndrome: Comprehensive Clinical Study in Genetically Confirmed 60 Japanese Patients

  • by Tomoe Ogawa, Hiromune Narusawa, Keisuke Nagasaki, Rika Kosaki, Yasuhiro Naiki, Michihiko Aramaki, Keiko Matsubara, Akie Nakamura, Maki Fukami, Tsutomu Ogata, Masayo Kagami

  • December 18, 2024

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