Case Report: Invasive pulmonary aspergillosis caused by Aspergillus lentulus in a boy with chronic granulomatous disease - Takeaways - MDSpire

Case Report: Invasive pulmonary aspergillosis caused by Aspergillus lentulus in a boy with chronic granulomatous disease

  • By

  • Shan Tan

  • Qiong Liao

  • Yang Wen

  • Yu Zhu

  • June 2, 2026

  • 0 min

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  • 1

    Aspergillus lentulus is a drug-resistant fungus causing invasive pulmonary aspergillosis, primarily reported in immunocompromised adults.

  • 2

    This case highlights a rare instance of invasive pulmonary aspergillosis due to Aspergillus lentulus in a pediatric patient with chronic granulomatous disease.

  • 3

    The patient presented with prolonged fever and was diagnosed through chest CT and metagenomic next-generation sequencing.

  • 4

    Combination therapy with voriconazole and micafungin led to clinical improvement and eventual discharge after 44 days of hospitalization.

  • 5

    This case emphasizes the importance of identifying the causative organism and the potential of mNGS in diagnosing rare fungal infections.

Original Source(s)

Case Report: Invasive pulmonary aspergillosis caused by Aspergillus lentulus in a boy with chronic granulomatous disease

  • by Shan Tan, Qiong Liao, Yang Wen, Yu Zhu

  • June 2, 2026

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