Fibrinogen-to-red blood cell ratio is associated with disease burden and short-term outcomes in hospitalized patients with gout: comparison with conventional inflammatory indices

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The study evaluated the fibrinogen-to-red blood cell ratio (FRR) in relation to disease severity and outcomes in hospitalized gout patients.
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High FRR was associated with more frequent annual flares, higher CRP and ESR levels, and longer hospital stays compared to low FRR.
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FRR demonstrated stronger correlations with inflammatory markers than traditional indices like the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
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After adjustments, higher FRR was independently linked to increased annual flare frequency, tophi presence, proteinuria, and 30-day readmission rates.
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FRR showed higher area under the curve (AUC) values than NLR and PLR for predicting tophi, proteinuria, and 30-day readmission.

Frontiers In Medicine

by Hao-Jie Zhong, Shu-Juan Chen, Xiao-Lan Qian, Min Xiao, Gui-Chen Ling, Jian-Yong Zhang, Jing-Jing Xie
July 15, 2026

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