High-grade astrocytoma with piloid features: a case report of comprehensive management

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High-grade astrocytoma with piloid features (HGAP) is a rare tumor classified by the 2021 WHO due to its unique DNA methylation profile.
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The case study describes a 35-year-old female with progressive numbness, diagnosed with HGAP after imaging and histopathological analysis.
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Surgical resection followed by radiotherapy and temozolomide chemotherapy was administered, with the patient showing no significant adverse events.
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Postoperative MRI indicated early radiological progression, highlighting the aggressive nature of HGAP and the need for careful monitoring.
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HGAP primarily occurs in the posterior cranial fossa, with symptoms related to tumor location, including headaches and sensory disturbances.

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