Case Report: Epidemiology, clinical features and progress in disease management for lymphoepithelial carcinoma of salivary glands: report of 3 cases - Takeaways - MDSpire

Case Report: Epidemiology, clinical features and progress in disease management for lymphoepithelial carcinoma of salivary glands: report of 3 cases

  • By

  • Shunyi Huang

  • Cenwen Liu

  • Xueying Zeng

  • Zihan Huang

  • Feng Lin

  • Yongyuan Chen

  • Guanxiang Zhuo

  • Jiahui Lin

  • Dawei Lin

  • Qinqin Chen

  • Xinxin Chen

  • Yunyun Mei

  • Qing Guan

  • July 17, 2026

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  • 1

    Lymphoepithelial carcinoma is a rare malignant tumor in salivary glands, accounting for approximately 0.4% of such tumors.

  • 2

    The majority of lymphoepithelial carcinoma cases arise from the parotid gland, with Epstein-Barr virus implicated in its etiology.

  • 3

    Three cases of lymphoepithelial carcinoma were reported, with two patients experiencing cervical lymph node metastasis.

  • 4

    Two of the three patients followed up for 15 months showed no local recurrence or distant metastasis after treatment.

  • 5

    Combination therapy involving surgery and radiotherapy is the current standard, with potential for future targeted and immunotherapy.

Original Source(s)

Case Report: Epidemiology, clinical features and progress in disease management for lymphoepithelial carcinoma of salivary glands: report of 3 cases

  • by Shunyi Huang, Cenwen Liu, Xueying Zeng, Zihan Huang, Feng Lin, Yongyuan Chen, Guanxiang Zhuo, Jiahui Lin, Dawei Lin, Qinqin Chen, Xinxin Chen, Yunyun Mei, Qing Guan

  • July 17, 2026

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