Altered spontaneous brain activity and functional connectivity in persistent postural-perceptual dizziness - Takeaways - MDSpire

Altered spontaneous brain activity and functional connectivity in persistent postural-perceptual dizziness

  • By

  • Jinghan Qin

  • Weitao Wang

  • Liya Shen

  • Yaru Liu

  • Tiancan Jin

  • Juan Wang

  • Daopei Zhang

  • Huailiang Zhang

  • July 15, 2026

Share

  • 1

    Persistent postural-perceptual dizziness (PPPD) is characterized by chronic dizziness and postural instability exacerbated by upright posture and complex visual stimuli.

  • 2

    The study involved 21 PPPD patients and 23 healthy controls, utilizing 3.0 Tesla resting-state functional MRI to assess brain activity and connectivity.

  • 3

    Patients with PPPD exhibited altered brain activity in regions including the cerebellum, occipital and temporal cortices, and anterior cingulate cortex.

  • 4

    Functional connectivity analyses revealed abnormal connections among key brain regions, including the insula, caudate nucleus, and prefrontal cortex.

  • 5

    Clinical correlations indicated that disease duration, dizziness handicap, anxiety severity, and cognitive performance were linked to functional changes in specific brain regions.

Original Source(s)

Altered spontaneous brain activity and functional connectivity in persistent postural-perceptual dizziness

  • by Jinghan Qin, Weitao Wang, Liya Shen, Yaru Liu, Tiancan Jin, Juan Wang, Daopei Zhang, Huailiang Zhang

  • July 15, 2026

Related Content

Thyroid autoimmunity and spontaneous cervicocranial artery dissection: an exploratory segment-specific case-control study

Feasibility and preliminary signal of cerebellar intermittent theta burst stimulation for static balance in cerebellar ataxia: a pilot study

Risk prediction models for postherpetic neuralgia: a systematic review and meta-analysis