Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis - Takeaways - MDSpire

Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis

  • By

  • Xiaohan Wang

  • Shiyu You

  • Shihan Tang

  • Ying Xie

  • Dongmei Wu

  • March 16, 2026

  • 0 min

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  • 1

    The pooled prevalence of comorbid depression among youth with type 2 diabetes mellitus is 23.1%, indicating a significant mental health concern.

  • 2

    Subgroup analyses revealed that prevalence varies significantly by HbA1c levels and assessment methods used in studies.

  • 3

    Participants with HbA1c levels below 7% exhibited a higher prevalence of depression at 52.0% compared to 24.0% for those with levels at or above 7%.

  • 4

    Self-report scales indicated a higher prevalence of depression (25.2%) than clinical diagnostic criteria (12.2%), highlighting assessment method impact.

  • 5

    The findings emphasize the need for standardized diagnostic procedures and early psychological screening in pediatric T2DM populations.

Original Source(s)

Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis

  • by Xiaohan Wang, Shiyu You, Shihan Tang, Ying Xie, Dongmei Wu

  • March 16, 2026

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