Microbiome-orchestrated cross-organ immunity in autoimmunity: from metabolites to therapeutic targets - Takeaways - MDSpire

Microbiome-orchestrated cross-organ immunity in autoimmunity: from metabolites to therapeutic targets

  • By

  • Xianlin Rao

  • Li Zou

  • Xiaoyu Cai

  • Yao Yao

  • Lingling Zhong

  • May 25, 2026

  • 0 min

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  • 1

    Autoimmune diseases are systemic disorders influenced by gut microbial ecology, affecting multiple organs beyond the gut.

  • 2

    Microbiota-derived metabolites serve as biochemical links between intestinal health and extraintestinal immune pathology.

  • 3

    The review emphasizes a metabolite-centered model to understand cross-organ immunity in autoimmune diseases.

  • 4

    Therapeutic strategies include dietary modulation, probiotics, and targeting metabolite receptors to address autoimmunity.

  • 5

    The concept of cross-organ immunity integrates immune priming, metabolite signaling, and tissue-specific inflammation.

Original Source(s)

Microbiome-orchestrated cross-organ immunity in autoimmunity: from metabolites to therapeutic targets

  • by Xianlin Rao, Li Zou, Xiaoyu Cai, Yao Yao, Lingling Zhong

  • May 25, 2026

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