Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical - Takeaways - MDSpire

Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical

  • By

  • T. John Winhusen

  • Michelle R. Lofwall

  • Frankie Kropp

  • Daniel Lewis

  • Marcela C. Smid

  • Jessica L. Young

  • Candace Hodgkins

  • Elizabeth E. Krans

  • Zachary Hansen

  • Elisha M. Wachman

  • Davida M. Schiff

  • Constance Guille

  • Vania Rudolf

  • Tara Chowdhury

  • Lawrence Leeman

  • Mitra Lewis

  • Abigail G. Matthews

  • Gerald Cochran

  • Jacquie King

  • Christine Wilder

  • Carmen Rosa

  • May 1, 2026

  • 0 min

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  • 1

    This study compares the effectiveness and safety of extended-release buprenorphine to sublingual buprenorphine in pregnant individuals with opioid use disorder.

  • 2

    Participants were randomized 1:1 to receive either extended-release or sublingual buprenorphine, with a focus on illicit opioid abstinence as the primary outcome.

  • 3

    The trial was conducted at 13 US sites and included weekly visits for participants through 12 months postpartum, emphasizing collaborative care models.

  • 4

    Exclusion criteria included physiological dependence on alcohol or sedatives, psychiatric conditions, and current or planned enrollment in higher-level treatments.

  • 5

    The study aimed to address the disadvantages of sublingual buprenorphine, such as poor adherence and risk of misuse, particularly during pregnancy.

Original Source(s)

Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical

  • by T. John Winhusen, Michelle R. Lofwall, Frankie Kropp, Daniel Lewis, Marcela C. Smid, Jessica L. Young, Candace Hodgkins, Elizabeth E. Krans, Zachary Hansen, Elisha M. Wachman, Davida M. Schiff, Constance Guille, Vania Rudolf, Tara Chowdhury, Lawrence Leeman, Mitra Lewis, Abigail G. Matthews, Gerald Cochran, Jacquie King, Christine Wilder, Carmen Rosa

  • May 1, 2026

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