Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection - Takeaways - MDSpire

Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection

  • By

  • Valentina Artusa

  • Roberta Zamarato

  • Lara De Luca

  • Livia Benedetti

  • Mirko Compagno

  • Mario Alberto Cano Fiestas

  • Diego Bottan

  • Mario Clerici

  • Mara Biasin

  • Daria Trabattoni

  • the MARISA Study Group

  • July 15, 2026

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  • 1

    Persistent immune activation and inflammation in HIV-infected individuals contribute to non-AIDS comorbidities despite long-term virological suppression.

  • 2

    Distinct mucosal transcriptional patterns correlate with clinical status, ART regimen, and immune recovery in virologically suppressed individuals.

  • 3

    INSTI-based therapy enhances epithelial junctional remodelling, leading to improved gut barrier integrity in HIV-infected individuals.

  • 4

    Mucosal analyses reveal spatially restricted epithelial-immune regulation, which is not reflected in peripheral cellular and circulating biomarkers.

  • 5

    Ongoing intestinal barrier dysfunction in treated HIV infection is associated with increased risk of non-AIDS comorbidities and systemic inflammation.

Original Source(s)

Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection

  • by Valentina Artusa, Roberta Zamarato, Lara De Luca, Livia Benedetti, Mirko Compagno, Mario Alberto Cano Fiestas, Diego Bottan, Mario Clerici, Mara Biasin, Daria Trabattoni, the MARISA Study Group

  • July 15, 2026

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