Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma - Takeaways - MDSpire
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Selective Exclusion of Post-Surgical Neck Radiation in Certain pN0 Patients with Advanced Oral Cavity Squamous Cell Carcinoma

  • By

  • Mathilde Mirallié

  • Anouchka Modesto

  • Marie Pajiep

  • Sébastien Vergez

  • Jérôme Sarini

  • Lucie Piram

  • Céline Dalmasso

  • Benjamin Vairel

  • Emilien Chabrillac

  • Agnès Dupret-Bories

  • June 15, 2026

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  • 1

    Head and neck cancers are the seventh most common malignancy globally, with oral cavity squamous cell carcinoma being the most frequent subtype.

  • 2

    Postoperative neck irradiation remains controversial for patients with pathologically node-negative necks after surgery for advanced oral cavity squamous cell carcinoma.

  • 3

    The adequacy of surgical staging, particularly the number of lymph nodes retrieved, is a critical factor in determining the need for postoperative neck irradiation.

  • 4

    This study evaluates overall survival, disease-free survival, and locoregional control in patients with pT3–T4 pN0 oral cavity squamous cell carcinoma.

  • 5

    The decision to omit postoperative neck irradiation was made based on preoperative imaging and the quality of neck dissection in a multidisciplinary tumor board.

Original Source(s)

Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma

  • by Mathilde Mirallié, Anouchka Modesto, Marie Pajiep, Sébastien Vergez, Jérôme Sarini, Lucie Piram, Céline Dalmasso, Benjamin Vairel, Emilien Chabrillac, Agnès Dupret-Bories

  • June 15, 2026

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