Impact of extranodal involvement at CAR T-cell therapy on outcomes in patients with relapsed or refractory large B-cell lymphoma—Results from a multicenter cohort study - Takeaways - MDSpire

Impact of extranodal involvement at CAR T-cell therapy on outcomes in patients with relapsed or refractory large B-cell lymphoma—Results from a multicenter cohort study

  • By

  • Frederique St-Pierre

  • Subodh Bhatta

  • Peter G. Doukas

  • Madeline Jenkin

  • Kaitlin Annunzio

  • Alexandra E. Rojek

  • Alyssa Gibson

  • Yun Kyoung Tiger

  • Brittany McCall

  • Khaled Alhamad

  • Alec Hansen

  • Juan P. Alderuccio

  • Olutobi Adewale

  • Keem Patel

  • Asaad Trabolsi

  • Izidore S. Lossos

  • Lindsey Fitzgerald

  • Thomas A. Ollila

  • Matthew J. Matasar

  • Justin Kline

  • Reem Karmali

  • Narendranath Epperla

  • June 21, 2025

  • 0 min

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  • 1

    Extranodal involvement in diffuse large B-cell lymphoma (DLBCL) is common, affecting up to 50% of patients at diagnosis.

  • 2

    CAR T-cell therapy has transformed treatment for relapsed or refractory DLBCL, but outcomes for patients with extranodal disease remain unclear.

  • 3

    This multicenter study analyzed 218 patients with extranodal relapsed or refractory large B-cell lymphoma receiving CAR T-cell therapy.

  • 4

    Overall response rate (ORR) and complete response rate (CRR) were 62% and 40%, respectively, following CAR T-cell therapy.

  • 5

    Cytokine release syndrome (CRS) occurred in 73% of patients, with 6% experiencing severe CRS, highlighting significant treatment-related toxicities.

Original Source(s)

Impact of extranodal involvement at CAR T-cell therapy on outcomes in patients with relapsed or refractory large B-cell lymphoma—Results from a multicenter cohort study

  • by Frederique St-Pierre, Subodh Bhatta, Peter G. Doukas, Madeline Jenkin, Kaitlin Annunzio, Alexandra E. Rojek, Alyssa Gibson, Yun Kyoung Tiger, Brittany McCall, Khaled Alhamad, Alec Hansen, Juan P. Alderuccio, Olutobi Adewale, Keem Patel, Asaad Trabolsi, Izidore S. Lossos, Lindsey Fitzgerald, Thomas A. Ollila, Matthew J. Matasar, Justin Kline, Reem Karmali, Narendranath Epperla

  • June 21, 2025

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