Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort - Takeaways - MDSpire

Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort

  • By

  • Xuemei Wang

  • Caiyun Wu

  • Lin Su

  • Jing Wang

  • Yu Li

  • Feng Ni

  • Hong Jiang

  • July 8, 2026

  • 0 min

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  • 1

    The study analyzed 425 men from the RHCC-AC cohort to investigate the impact of metal exposure on sperm quality.

  • 2

    Al was positively associated with sperm abnormality rate, while Co and Cu were inversely associated with sperm motility.

  • 3

    Mixture analyses indicated that Al and Co were primary contributors to increased sperm abnormality and reduced motility, respectively.

  • 4

    D,L-ortho-tyrosine mediated the associations of mercury and vanadium with sperm concentration, with proportions of 11.8% and 13.0%.

  • 5

    The findings suggest a complex relationship between metal exposure, oxidative stress, and sperm quality, warranting further research.

Original Source(s)

Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort

  • by Xuemei Wang, Caiyun Wu, Lin Su, Jing Wang, Yu Li, Feng Ni, Hong Jiang

  • July 8, 2026

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