Beyond adrenal suppression: a comprehensive post-marketing safety profile of etomidate from real world data

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Etomidate is an intravenous anesthetic with concerns regarding adverse drug reactions beyond adrenal suppression.
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A retrospective study analyzed data from the FDA Adverse Event Reporting System from 2004 to 2025 to evaluate etomidate's safety.
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The study identified 318 adverse drug reactions, with novel signals including cardiac arrest, seizure, and drug abuse associated with etomidate.
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Cardiac disorders were significantly associated with etomidate, while endocrine disorders emerged as a novel signal.
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The findings highlight the importance of ongoing safety surveillance for etomidate to better understand its long-term safety profile.

Frontiers In Medicine

by Huiyi Deng, Wujiang Lai, Ying Xiang, Zewen Wang, Jiemei Liang, Yiwen Zhang, Jiale Liang
July 7, 2026

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