Case Report: Adult-onset Still’s disease presenting with massive hemorrhagic pericardial effusion without the characteristic rash - Takeaways - MDSpire

Case Report: Adult-onset Still’s disease presenting with massive hemorrhagic pericardial effusion without the characteristic rash

  • By

  • Yun Li

  • Ning Wang

  • Junqi Hu

  • Changsheng Xie

  • Junchao Yang

  • Tingzhen Xu

  • June 4, 2026

  • 0 min

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  • 1

    Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disorder with no universally accepted disease-specific biomarkers.

  • 2

    Diagnosis of AOSD relies on clinical manifestations, laboratory abnormalities, and exclusion of alternative diagnoses using criteria like Yamaguchi or Fautrel.

  • 3

    AOSD can present atypically, such as with massive hemorrhagic pericardial effusion, without the characteristic rash, complicating diagnosis.

  • 4

    A 67-year-old man presented with fever and cough, ultimately diagnosed with AOSD after ruling out tuberculosis and malignancy.

  • 5

    The patient's rapid response to glucocorticoid therapy supported the diagnosis of AOSD, highlighting the need for awareness of atypical presentations.

Original Source(s)

Case Report: Adult-onset Still’s disease presenting with massive hemorrhagic pericardial effusion without the characteristic rash

  • by Yun Li, Ning Wang, Junqi Hu, Changsheng Xie, Junchao Yang, Tingzhen Xu

  • June 4, 2026

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