Predicting propofol requirements in advanced gastrointestinal endoscopy: a validated model incorporating age and comorbidity index

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The study evaluated the association between comorbidity burden and propofol requirements during advanced gastrointestinal endoscopy.
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A total of 1,555 adult patients were included, undergoing procedures under BIS-guided TCI propofol sedation.
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Older age, male sex, longer procedure duration, and higher CCI were linked to lower propofol requirements in multivariable analysis.
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The model demonstrated good discrimination with AUC values of 0.831 in the training cohort and 0.841 in the validation cohort.
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External validation of the proposed model is necessary before clinical application in individualized sedation management.

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