Favorable clinical and microbiological outcomes of a war-associated prosthetic joint infection caused by Klebsiella pneumoniae treated with combined phage-colistin therapy - Takeaways - MDSpire
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Successful Clinical and Microbiological Results in a War-Related Prosthetic Joint Infection Due to Klebsiella pneumoniae Treated with Combined Phage and Colistin Therapy

  • By

  • Lucas Mora-Quilis

  • Mireia Bernabéu-Gimeno

  • Marco Pardo-Freire

  • Sergio García-Porto

  • Valentín Yuste-Benavente

  • María del Mar Rodero-Roldán

  • Pilar Domingo-Calap

  • September 9, 2026

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  • 1

    A 52-year-old man with war-related injuries developed a persistent prosthetic elbow infection caused by multidrug-resistant Klebsiella pneumoniae.

  • 2

    After 4 weeks of intravenous antibiotics, he received a 14-week multidrug regimen with repeated surgical debridement, but the infection later recurred.

  • 3

    After conventional antimicrobial therapy failed, personalized phage therapy was initiated with colistin and surgical debridement as an adjunctive treatment.

  • 4

    The selected lytic phage showed high activity against all 6 K. pneumoniae isolates from the patient, with susceptibility confirmed by agar and liquid-culture testing.

  • 5

    The combined treatment was well tolerated, with no reported adverse effects, and was associated with progressive wound healing, partial recovery of elbow mobility, and sustained microbiological clearance during available follow-up.

Original Source(s)

Favorable clinical and microbiological outcomes of a war-associated prosthetic joint infection caused by Klebsiella pneumoniae treated with combined phage-colistin therapy

  • by Lucas Mora-Quilis, Mireia Bernabéu-Gimeno, Marco Pardo-Freire, Sergio García-Porto, Valentín Yuste-Benavente, María del Mar Rodero-Roldán, Pilar Domingo-Calap

  • September 9, 2026

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