Pentraxin-3 as a Systemic Indicator of Pathology and a Local Inflammatory Mediator in Thyroid Nodules

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Pentraxin-3 (PTX3) is an inflammatory mediator involved in inflammation, tissue remodeling, and oncogenesis in thyroid pathology.
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Preoperative plasma PTX3 levels were significantly elevated in patients with thyroid nodules and declined after surgery.
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PTX3 expression was significantly higher in malignant thyroid tissues compared to healthy thyroid tissues.
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No significant differences in plasma PTX3 levels were observed between benign and malignant thyroid conditions.
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The study suggests that PTX3 may indicate inflammation or tissue stress in thyroid nodular disease, but its specificity remains undetermined.

Frontiers In Endocrinology

by Miriam Cieri, Fabio Grizzi, Barbara Bottazzi, Giorgia Amy Rodda, Paola Petrillo, Roberto Leone, Fabio Pasqualini, Emanuela Morenghi, Walter Zuliani, Silvia Uccella, Damiano Chiari
July 17, 2026

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