AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective - Takeaways - MDSpire

AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective

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AIRE enables mTECs to express a selective repertoire of tissue-restricted antigens, supporting central T-cell tolerance.
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AIRE forms transcriptionally active condensates that coordinate chromatin recognition, cofactor recruitment, and transcriptional elongation.
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Sparse TRA expression in mTECs reflects the low probability of a locus reaching a permissive chromatin state.
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AIRE preferentially associates with regulatory-factor-rich chromatin environments rather than isolated recognition sites.
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AIRE-induced gene expression is characterized by sparse, heterogeneous, and modular output across mTECs.

Frontiers In Immunology

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