miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity - Takeaways - MDSpire

miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity

  • By

  • Harshita Shailesh

  • Mohamed Nadhir Djekidel

  • Safa Noor

  • Lena Hayati

  • Stefan Worgall

  • Souhaila Al Khodor

  • Ibrahim Janahi

  • May 13, 2026

  • 0 min

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  • 1

    Pediatric obesity is a significant risk factor for asthma, linked to increased disease severity and reduced corticosteroid effectiveness.

  • 2

    The study identified distinct circulating miRNA profiles associated with asthma-obesity comorbidity in children, highlighting potential biomarkers.

  • 3

    Five miRNAs were consistently upregulated, while two were downregulated across different cohorts, indicating specific molecular signatures.

  • 4

    Altered miRNA expression in overweight/obese children with asthma correlated with increased neutrophil counts and pro-inflammatory cytokines.

  • 5

    Understanding these miRNA profiles may lead to targeted therapeutic strategies for managing asthma in pediatric patients with obesity.

Original Source(s)

miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity

  • by Harshita Shailesh, Mohamed Nadhir Djekidel, Safa Noor, Lena Hayati, Stefan Worgall, Souhaila Al Khodor, Ibrahim Janahi

  • May 13, 2026

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