Tenecteplase vs Alteplase and Time to Treatment for Acute Ischemic Stroke

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Initiating reperfusion therapy sooner after acute ischemic stroke onset improves clinical outcomes.
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Tenecteplase offers shorter preparation and administration times compared to alteplase for ischemic stroke treatment.
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The study aimed to compare door-to-needle and door-in-door-out times between tenecteplase and alteplase patients.
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Hospitals were categorized based on tenecteplase utilization rates, influencing treatment workflow efficiency.
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Data were analyzed from the Get With The Guidelines–Stroke database, capturing over 75% of US stroke admissions.

Jama Network Open

by Steven J. Warach, Jeremy M. Weber, Brooke Alhanti, Steven R. Messé, Lee H. Schwamm, Gregg C. Fonarow, Kevin N. Sheth, Eric E. Smith, Michael T. Mullen, Gisele Sampaio Silva, Brian Mac Grory, Ying Xian, Jeffrey L. Saver
July 13, 2026

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