Omalizumab for severe IgE-mediated food allergy and severe asthma after pediatric liver transplantation: a case report - Takeaways - MDSpire
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Omalizumab in the Management of Severe IgE-Mediated Food Allergies and Asthma Following Pediatric Liver Transplantation: A Case Study

  • By

  • Antonella Mosca

  • Andrea Ficari

  • Maria Sole Basso

  • Carmen Mazzuca

  • Daniela Liccardo

  • Alessandro Fiocchi

  • Andrea Pietrobattista

  • Vincenzo Fierro

  • June 17, 2026

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  • 1

    De novo post-transplant food allergy (dnPTFA) is common in pediatric liver transplant recipients, with prevalence significantly higher than in the general population.

  • 2

    Risk factors for dnPTFA include young age, female sex, atopy history, immunosuppressive therapy, and Epstein–Barr virus infection.

  • 3

    A 15-year-old boy developed severe asthma and multiple dnPTFAs after liver transplantation, despite low immunosuppression levels.

  • 4

    Omalizumab was initiated off-label at age 10, leading to excellent asthma control and a less restricted diet for the patient.

  • 5

    The patient's liver graft function remained stable over 5 years, supporting the long-term safety and effectiveness of omalizumab in this context.

Original Source(s)

Omalizumab for severe IgE-mediated food allergy and severe asthma after pediatric liver transplantation: a case report

  • by Antonella Mosca, Andrea Ficari, Maria Sole Basso, Carmen Mazzuca, Daniela Liccardo, Alessandro Fiocchi, Andrea Pietrobattista, Vincenzo Fierro

  • June 17, 2026

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